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Journal of Vascular Surgery

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Presentation on theme: "Journal of Vascular Surgery"— Presentation transcript:

1 Journal of Vascular Surgery
Vascular Cell Adhesion Molecule 1 Is a Promising Target to Identify High-Risk Carotid Plaques Using Contrast-Enhanced Duplex Ultrasound  Craig C. Weinkauf, MD, PhD, Scott S. Berman, MD, MHA, Kay Goshima, MD, Luis R. Leon, MD, Edmund R. Marinelli, PhD, Rebecca Millius, MD, Evan C. Unger, MD  Journal of Vascular Surgery  Volume 64, Issue 2, (August 2016) DOI: /j.jvs Copyright © Terms and Conditions

2 Fig 1 Carotid endarterectomy plaques have differential histology features. Formalin-fixed, decalcified carotid endarterectomy plaques were evaluated with trichrome staining by light microscopy (magnification ×10). Asymptomatic (A) plaques have low-risk features with uniform cholesterol-rich, calcified plaque (C). Symptomatic plaques (B) have a varying combination of high-risk features including lipid-rich necrotic core (D), inflammatory infiltrate (E), and intraplaque hemorrhage (F). L, Lumen. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

3 Fig 2 V-CAM Selectively Stains High-Risk Carotid Plaques. IHC staining of 30 asymptomatic (A) and 30 symptomatic (S) CEA plaques with Anti-VCAM (1:200) were blindly graded on a 0-4 scale. Staining is seen best along the endothelium (arrows). Grade 0 = minimal staining; grade 4 = highest staining, see A1-A4. Symptomatic plaques had significantly higher VCAM staining (B) compared to asymptomatic plaques, of which 76.5% had low VCAM staining (C) as defined as grade 0 or 1. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

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