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Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E

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Presentation on theme: "Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E"— Presentation transcript:

1 Effects of environmental tobacco smoke exposure on pulmonary immune response in infant monkeys 
Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E. Pinkerton, PhD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 2, Pages e5 (August 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Relative levels of expression of mRNA for IFN-γ (A) and IL-2 (B) in lung tissue from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS compared with FA, P < .05. †Postnatal ETS compared with FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Relative levels of mRNA expression for IP-10 (A), MIG (B), ITAC (C), and TARC (D) in lung tissue from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS vs FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 The effect of ETS exposure on the mRNA expression of CXCR3 (A), CCR5 (B), CCR3 (C), and CCR4 (D) in the lung from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS vs FA, P < .05. †Postnatal ETS vs FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Localization of CXCR3-positive cells in the airway. A, The subepithelium of a representative FA-exposed control lung has immune cells immunostained positive for CXCR3 (arrow). B, Lung tissue from a perinatal ETS-exposed monkey. C, Lung tissue from a postnatal ETS-exposed monkey. Magnification bar: 50 μm. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 The effect of ETS exposure on the number of CXCR3-positive cells in the subepithelium. The number of positive cells per square micrometer subepithelium in lung tissue from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. Data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS vs FA, P < .05. †Postnatal ETS vs FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 6 The effect of ETS exposure on the regulatory cytokines IL-12p70 (A) and IL-10 (B) in the lungs from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS vs FA, P < .05. †Postnatal ETS vs FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig 7 Relative levels of mRNA expression for transcription factor T-bet (A) and GATA-3 (B) in lung tissues from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). ∗Perinatal ETS vs FA, P < .05. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Relative levels of expression of mRNA for IL-4 and IL-13 in lung tissue from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Relative levels of expression of mRNA for TH2 chemokine eotaxin in lung tissue from FA-exposed, perinatal ETS-exposed, or postnatal ETS-exposed infant monkeys. The data are expressed as the means ± SEMs (n = 5). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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