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National Cancer Institute–National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplant Consortium First International Consensus Conference.

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Presentation on theme: "National Cancer Institute–National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplant Consortium First International Consensus Conference."— Presentation transcript:

1 National Cancer Institute–National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplant Consortium First International Consensus Conference on Late Effects After Pediatric Hematopoietic Cell Transplantation: Long-Term Organ Damage and Dysfunction  Michael L. Nieder, George B. McDonald, Aiko Kida, Sangeeta Hingorani, Saro H. Armenian, Kenneth R. Cooke, Michael A. Pulsipher, K. Scott Baker  Biology of Blood and Marrow Transplantation  Volume 17, Issue 11, Pages (November 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Proposed conceptual representation of pathogenesis of CKD in HCT recipients. aGVHD, acute GVHD; cGVHD, chronic GVHD; HTN, hypertension. From Hingorani S. Kidney and bladder complications of hematopoietic cell transplantation. In: Thomas ED, Appelbaum FR, Forman SG, et al., editors. Hematopoietic Cell Transplantation. 4th ed. Hoboken, NJ: Wiley-Blackwell; p Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence curves of albuminuria and nonrelapse mortality from day 100 to 1 year post-HCT: n = 43 for albumin/creatinine ratio (ACR) <30; n = 54 for ACR ; n = 17 for ACR ≥300. Hingorani SR, Seidel K, Lindner A, Aneja T, Schoch G, McDonald G. Albuminuria in hematopoietic cell transplantation patients: prevalence, clinical associations, and impact on survival. Biol Blood Marrow Transplant Dec;14(12): Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Kaplan-Meier curves of albuminuria and overall survival from day 100 to 1 year post-HCT: n = 44 for albumin/creatinine ratio (ACR) <30; n = 58 for ACR ; n = 18 for ACR ≥300. Hingorani SR, Seidel K, Lindner A, Aneja T, Schoch G, McDonald G. Albuminuria in hematopoietic cell transplantation patients: prevalence, clinical associations, and impact on survival. Biol Blood Marrow Transplant Dec;14(12): Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Mechanisms of cellular damage and organ response.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions


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