1. TLR7 Structure: Cut in Z-Loop
Kazuhiko Maeda, Shizuo Akira 
Immunity 
Volume 45, Issue 4, Pages (October 2016)
DOI: /j.immuni
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2. Figure 1
Schematic View of TLR7-TLR8-TLR9 Subfamily and Their Ligand Binding Sites
All members of the TLR7-TRL8-TLR9 subfamily possess the Z-loop (red strings) in the leucine rich repeat (LRR). Z-loop processing is required for activation of these TLRs. Guanosine and uridine-rich ssRNA bind to the first and second site of TLR7, respectively. Uridine and short ssRNA bind to the first and second site of TLR8, respectively. TLR9 binds to single-stranded unmethylated CpG-DNA.
Immunity  , DOI: ( /j.immuni )
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