Download presentation
Presentation is loading. Please wait.
1
Volume 65, Issue 2, Pages 403-408 (February 2004)
Glucocorticoid receptors, in vitro steroid sensitivity, and cytokine secretion in idiopathic nephrotic syndrome Ana Paula de Carvalho, Panzeri Carlotti, Paulo Benedito Franco, Lucila Leico Elias, Inalda Facincani, Elaine Lourenço, Cardeal Costa, Norma Foss, Ayrton Custódio Moreira, Margaret de Castro Kidney International Volume 65, Issue 2, Pages (February 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions
2
Figure 1 Representative saturation curves of [3H] dexamethasone binding to peripheral blood mononuclear cell (PBMC) and the Scatchard plot (insert) of glucocorticoid receptor (GR) binding studies of a steroid-sensitive (SS) patient (•), a steroid-resistant (SR2) patient (Δ), and a normal patient (♦). Kidney International , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions
3
Figure 2 Percentage of inhibition of lymphocyte proliferation after incubation in RPMI with concanavalin-A (Con-A) plus different doses of dexamethasone (10-8, 10-6, and 10-4 mol/L) in healthy control patients, steroid-sensitive (SS) patients (•), and steroid-resistant (SR) patients: SR1 (□), SR2 (Δ), SR3 (○). Boxes indicate the 95% CI in control patients. Kidney International , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions
4
Figure 3 Percentage of inhibition of interferon (IFN)-γ and tumor necrosis factor (TNF)-α (A), and interleukin (IL)-10 and IL-6 (B) cytokine secretion after peripheral blood mononuclear cell (PBMC) incubation in RPMI with concanavalin-A (Con-A) plus different doses of dexamethasone (10-8, 10-6, and 10-4 mol/L) in healthy control patients, steroid-sensitive (SS) patients (•), and steroid-resistant (SR) patients: SR1 (□), SR2 (Δ), SR3 (○). Boxes indicate the 95% CI in control patients. Kidney International , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.