1. Zirconia – Alumina – Metal Primer

2. BISCO’s Z-PRIME Plus is a single-component priming agent used to create adhesion between indirect restorative materials and all resin containing cements.

3. Z-PRIME Plus - A proprietary Formula of concentrated MDP/Carboxylate monomers has been specifically formulated to address the current weakness in competitor’s primers and create a compelling reason to replace
them immediately!

4. Bisco Products v.s. Zirconia/Silane Competitors
Product Applications Components
Z-PRIME™ Plus
Bisco
Zirconia, Alumina, Metal
Silica-ceramics
Zirconia, Alumina, Metal, Silica-ceramics
BPDM, Phosphate,
Ethanol
Silane
Phosphate, Silane*
Porcelain Primer
Bisco
Monobond Plus
Ivoclar Vivadent
Clearfil Ceramic
Kuraray
*: Silane is not stable in the presence of acidic phosphate monomer.

5. Issue of Silane Incorporation into Zirconia Primers
Silane Primer
Zirconia/Silane Primer
Porcelain Primer
Bisco
Monobond Plus
Ivoclar Vivadent
Clearfil Ceramic
Kuraray
Contain: Silane
Contain: Silane & Acidic Phosphate pH
Self-Condensation of Hydrolyzed Silane
Silane Methacrylate
Pre-hydrolyzed Silane
De-activation of Silane
To maintain a good shelf-life, pH of one-bottle silane primer systems should be adjusted to 4-5.

6. Z-PRIME Plus Indications For Use
BISCO’s Z-PRIME™ PLUS is intended for use as a surface treatment for the following indirect restoration substrates:
Zirconia (e.g. Lava, Cerec, Implant & others)
Alumina (e.g. Procera)
Metal/alloy (Titanium, PFM, Non-Precious, High Noble)
Composite (Direct & Indirect)
Endodontic Posts (Zirconia, Metal, Fiber)
Intra-oral repairs

7. Primer Effect on Bond Strength of Resin Cements to Zirconia
Using the new primer had a significant effect on increasing the bond strength to zirconia of the tested cements between 86% and 160%  increase.
G. MILLAN, M. RAAD, M. ATTAR, and D. NATHANSON, Primer Effect on Bond Strength of Resin Cements to Zirconia, J Dent Res 89(Spec Issue A): Abstr. 1018, 2010

8. Strong Bond Strengths to Different Substrates
With Z-PRIME™ Plus with no primer
Cement-Self Cured
Zirconia
23 MPa
4 MPa
Alumina
18 MPa
3 MPa
Titanium
22 MPa
Non-precious
23 MPa
Stainless Steel
24 MPa
Gold
20 MPa
Composite
27 MPa

9. Unique Benefits
Unparalleled bond strengths to Zirconia, Alumina and Metal Restorations

10. High S/C & L/C Bonds
SBS of Z-PRIME™ Plus on Different Dental Substrates w/ Duolink™ 5 10 15 20 25 30 35
Fiber Post
Composite
Gold
Rex III
Option
Stainless Steel
Titanium
Ceramic
Alumina
Zirconia
SBS(MPa)
No Primer
ZPRIME+ -S/C
ZPRIME+ -L/C

11. not requiring refrigeration…
Bisco’s new DuoLink™ SE Kit including Z-PRIME Plus and Bis-Silane™ offers a system that provides “Confidence in Indirect Adhesion. The stability of the chemistry is demonstrated by
not requiring refrigeration…
New

12. **: Silane is not stable in the present of acidic phosphate monomer.
Competitors
Product Applications Components Shelf-life
Z-PRIME™ Plus
Bisco
Released 2009
Zirconia, Alumina, Metal
Zirconia, Alumina
Zirconia, Alumina, Metal, Silica-ceramics
2y/room temp.
2y/r.t.*(Duolink™)
2y/rom temp.
2y/refrig.*(ResiCem)
2y/refrig.*(Multilink)
2y/refrig.*(Multilink
2y/refrig
2y/refrig.*(Panavia)
BPDM, Phosphate,
Ethanol
Phosphonate,
Acetone
t-butyl alcohol
Phosphate, Silane**
AZ Primer
Shofu
Released 2009
Metal/Zr Primer
Ivoclar Vivadent
Monobond Plus
Ivoclar Vivadent
Released 2009
Clearfil Ceramic
Kuraray
**: Silane is not stable in the present of acidic phosphate monomer.
*: Shelf-life of its corresponding cement.

13. Unique Benefits
Compatible with light-cured and dual-cured resin luting cements

14. Stronger Bonding: SBS to Zirconia
Cement-Light Cured
Z-PRIME™ Plus
Duolink™
Bisco
29 MPa
Clearfil Ceramic
Panavia F2.0
Kuraray
8 MPa
AZ Primer
ResiCem
Shofu
21 MPa
Metal/Zr Primer
Multilink Automix
Ivoclar Vivadent
16 MPa
Monobond Plus
Multilink Automix
Ivoclar Vivadent
26 MPa

15. Stronger Bonding: SBS to Zirconia
Cement-Self Cured
Z-PRIME™ Plus
Duolink™
Bisco
23 MPa
Clearfil Ceramic
Panavia F2.0
Kuraray
9 MPa
AZ Primer
ResiCem
Shofu
13 MPa
Metal/Zr Primer
Multilink Automix
Ivoclar Vivadent
8 MPa
Monobond Plus
Multilink Automix
Ivaclar Vivadent
11 MPa

16. Durable Bonding: SBS to Zirconia
After Aging
Aged 3 days in boiling water, equiv. to 6 years at 37 °C. Cement-Light Cured.
Z-PRIME™ Plus
Duolink™
Bisco
29 MPa (Day 1)
28 MPa (6 years)
Clearfil Ceramic
Panavia F2.0
Kuraray
8 MPa (Day 1)
3 MPa (6 years)
AZ Primer
ResiCem
Shofu
21 MPa (Day 1)
18 MPa (6 years)
Monobond Plus
Multilink Automix
Ivoclar Vivadent
26 MPa (Day 1)
16 MPa (6 years)

17. Durable Bonding: SBS to Zirconia
After Aging
Aged 3 days in boiling water, equiv. to 6 years at 37 °C. Cement-Self Cured.
Z-PRIME™ Plus
Duolink™
Bisco
23 MPa (Day 1)
16 MPa (6 years)
Clearfil Ceramic
Panavia F2.0
Kuraray
9 MPa (Day 1)
2 MPa (6 years)
AZ Primer
ResiCem
Shofu
13 MPa (Day 1)
6 MPa (6 years)
Monobond Plus
Multilink Automix
Ivoclar Vivadent
11 MPa (Day 1)
7 MPa (6 years)

18. Comparison of Zirconia Restoration Luting Options: SBS to Zirconia
Cement-Self Cured
Resin Modified Glass Ionomer Cements
RelyX Luting+
(3M ESPE)
FujiCEM (GC)
SmartCem2
(Dentsply)
BisCem (Bisco)
UniCem (3M ESPE)
Z-Prime™ Plus
w/ Duolink™ (Bisco)
Duolink (Bisco)
4 MPa
8 MPa
Self-Adhesive Resin Cements
11 MPa
12 MPa
6 MPa
Primer w/ Resin Cement
23 MPa
Traditional Resin Cement without Primer (Control)
4 MPa

19. Average Shear Bond Strength of Zirconia Primers with their Corresponding Self-cure Resin Cements

20. Phosphate Monomer (MDP), BPDM, ethanol
Contains:
Phosphate Monomer (MDP), BPDM, ethanol
Strong Bond between Resin-cements/composites and:
Zirconia
Alumina
Metals
Titanium, Stainless steel, Rexilium, Option, Gold
Composites
Instruction for Use:
Apply 1-2 coats
Dry
Proceed with cementation.
Zr, Al, or
Metal etc
Dentin
Z-PRIME PLUS
Duolink

21. Technique For Placement
Clean the internal surface of the restoration; rinse and air dry.
Apply 1-2 coats of
Z-PRIME™ Plus, uniformly wetting the internal surface. Dry with an air syringe for 3-5 seconds.
Proceed with cementation using a luting cement (e.g. DUO-LINK™).

22. Cementing Zirconia Crowns
Z-Prime D Zr
BisCem
For Full/Retentive Zr Crowns use Biscem® with Z-PRIME™ Plus

23. Bonding Zirconia Crowns
Z-Prime D Zr
Adhesive
DuoLink Cement
Short/Tapered, Non-retentive Zr Crown adhesively bond with Resin Cement

24. New zirconia primer improves bond strength of resin-based cements.
“Improved marginal adaptation, prevention of microleakage,
increased fracture strength, and increased retention in
situations where mechanical retention does not exist constitute the benefits of a stable and durable resin bond to
zirconia.”
Magne P, et al. New zirconia primer improves bond strength of resin-based cements. Dent Mater (2009), doi: /j.dental
New zirconia primer improves bond strength of resin-based cements.

25. New zirconia primer improves bond strength of resin-based cements.
“The groups where the experimental zirconia primer (ZrP-groups) was used presented the highest mean bond strength values.”
“The groups that did not receive the experimental primer (NP groups)
and the group treated with the MDP-containing primer
(CCP-group) presented the lowest mean bond strength values”
Magne P, et al. New zirconia primer improves bond strength of resin-based cements. Dent Mater (2009), doi: /j.dental

26. “Confidence in Adhesion”
Proprietary MDP and carboxylic acid monomers
Significantly enhances bond strengths of other resin cements*
Compatible with light-cured and dual-cured resin luting cement
Convenient, single bottle delivery offers ease of dispensing
Fast/Predictable Cementation
*Data on file, BISCO, Inc.