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Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia  Shigeki Inui, Yoko Fukuzato,

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Presentation on theme: "Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia  Shigeki Inui, Yoko Fukuzato,"— Presentation transcript:

1 Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia  Shigeki Inui, Yoko Fukuzato, Takeshi Nakajima, Kunihiko Yoshikawa, Satoshi Itami  Journal of Investigative Dermatology Symposium Proceedings  Volume 8, Issue 1, Pages (June 2003) DOI: /j x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Alteration of expression level of AR in bald DPCs. (A) Bald DPCs were subcultured and their total RNA were recovered at the indicated passages (S3: the third passage, S9: the ninth passage). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 69-71DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Effect of R1881 on the proliferation of KCs cocultured with DPCs from bald frontal scalp skin of a male human, transiently transfected with pSG5-AR. The cells were cultured in the presence of ethanol as a mock (lane 1) or 10-9 M R1881 (lane 2). The graph shows cell numbers for KCs after coculturing for four days as a mean ± SD of three determinations. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 69-71DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Effect of R1881 on concentrations of TGF-β1 in conditioned media from cocultures of KCs and bald DPCs. After coculturing KCs and bald DPCs with ethanol (lane 1) or 10-9 M R1881 (lane 2) for four days, we harvested the conditioned media and then measured concentrations of TGF-β1 by an ELISA assay. In each case, the mean ± SD of three experiments is shown. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 69-71DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

5 Figure 4 Influence of the neutralizing antibody against TGF-β1 on the androgen-induced growth inhibition of KCs cocultured with bald DPCs. While coculturing KCs and bald DPCs with ethanol (lane 1) or 10-9 M R1881 (lanes 2, 3) treatment for four days, we incubated the cells together with preimmune mouse IgG (lanes 1 and 2) or anti-TGF-β1 antibody at a concentration of 5.0 (lane 3) μg/ml. The graph shows the cell numbers for KCs after coculturing for four days as the mean ± SD of three experiments. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 69-71DOI: ( /j x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

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