1. What’s All The Buzz About B’s?
Activated B-Complex
What’s All The Buzz About B’s?

2. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.

3. B Vitamins: Basics, Functions and Benefits
Water-soluble
Play roles as co-enzymes in the metabolism of protein, fat and carbohydrates
Support a healthy rate of metabolism
Help maintain healthy skin and muscle
Support immune and nervous system functions
Promote normal cell growth and division
Promotes energy
Promotes a healthy mental outlook, mood, memory
Supports a healthy heart system

4. B Vitamins Vitamin B1 (Thiamin) Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin B5 (Pantothenate)
Vitamin B6 (Pyridoxine)
Vitamin B (Biotin)
Vitamin B (Folic Acid)
Vitamin B12 (Cobalamin)

5. Advanced B-Complex Vs Activated B-Complex
Pyridoxal-5-Phosphate → Pyridoxal-5-Phosphate Folic Acid → Folinic Acid
Cyanocobalamin → Methylcobalamin

6. Vitamin B6 (Pyridoxal-5-Phosphate)
Presently in Advanced B-Complex
Pyridoxal-5-phosphate (P5P) is the main biologically active form of vitamin B6
Does not require activation by the liver

7. Pyridoxal-5-Phosphate: Physiological Functions
Supports numerous processes in the body
Catalyzes reactions involving amino acids (> 100 enzymes need)
Metabolism and usage of amino acids
Red blood cell metabolism and heme biosynthesis
Conversion of homocysteine to cysteine
Conversion of tryptophan to niacin
Involved in the synthesis of neurotransmitters in the brain and peripheral nerve cells

8. Pyridoxal-5-Phosphate: Research
Supplementation helps to correct vitamin B6 deficiency
Deficient levels of plasma P5P associated with:
Impaired amino acid enzyme activity
Neurological and mental performance
Higher plasma C-reactive protein (CRP) levels, oxidative stress, homocysteine, metabolic conditions
Heart health

9. folate → dihydrofolate → tetrahydrofolate ↔ methylene-THF → methyl-THF
Folinic acid
Folinic acid is a highly bioavailable metabolically active derivative of folic acid that can be readily converted into other reduced folic acid derivatives
folate → dihydrofolate → tetrahydrofolate ↔ methylene-THF → methyl-THF
Does not require dihydrofolate reductase to become active so not affected by medicines and herbs that inhibit this enzyme
Inhibition of enzyme can result in folic acid deficiency
Provides all vitamin activity equivalent to folic acid

10. Folic Acid: Physiological Functions
Support numerous processes in the body
DNA synthesis, repair, and methylation
Cell synthesis, maturation, and division
Especially important during fetal growth and for the production of red blood cells
Proper development of the nervous system
Per the FDA healthful diets containing adequate folate may reduce a woman’s risk of having a child with a brain or spinal cord defect
Regulation of homocysteine levels
Production of neurotransmitters and for healthy neurological functions
Deficiency implicated in the deterioration of memory and cognitive function associated with the aging process
Supports conversion of sulfur-containing compounds to glutathione

11. Folic Acid and MTHFR
Genetic variants in the MTHFR gene have a reduced methylenetetrahydrofolate reductase (enzyme) activity which can inhibit the levels of activated folic acid available
These variations have been linked to increased homocysteine levels which can effect heart health
Folinic acid, unlike folic acid, does not require the action of the enzyme MTHFR
Many metabolic processes can occur in the presence of MTHFR associated polymorphisms which may otherwise be inhibited

12. Methylcobalamin (Vitamin B12)
Methylcobalamin is a highly bioavailable metabolically active form of B12 (cobalamin).
Methylcobalamin and 5-deoxyadenosylcobalmin are the active forms of B12 used by the body
Cyanocobalamin is a synthetic form often used in supplements
Primary form used in treating B12 deficiency
Deficiencies can occur due to age, reduced ability to produce intrinsic factor, veganism, medications

13. Methylcobalamin: Physiological Functions
Supports numerous processes in the body
Transfer of methyl groups; necessary for methylation reactions
DNA synthesis and regulation
Cell synthesis, maturation and division
Especially important for the normal production of red blood cells
Conversion of homocysteine to methionine
Proper functioning of the nervous system
Methionine is necessary for the normal synthesis of myelin sheaths
Metabolism and utilization of carbohydrates, proteins and fats
Fatty acid synthesis and energy production
Production of SAMe (S-adenosyl-L-methionine)

14. Methylcobalamin and MTR
Genetic variation in the methionine synthase (MTR) gene appears to result in increased enzyme activity. This variation appears to have a positive effect on homocysteine levels.
Methylcobalamin is the specific form of B12 MTR uses as a co-enzyme in the conversion of homocysteine to methionine
Variants and non variants will benefit from use

15. Activated B-Complex 100 g MA Code: 13055 nutraMetrix: 13967 DC: $17.00
SR: $22.50
BV: 13

16. Activated B-Complex 300 g MA Code: 13057 nutraMetrix: 13965 DC: $39.00
SR: $49.95
BV: 30

17. Thank You and Good Night