1. Molecular mechanisms of renal hypertrophy: Role of p27Kip1
Gunter Wolf 
Kidney International 
Volume 56, Issue 4, Pages (October 1999)
DOI: /j x
Copyright © 1999 International Society of Nephrology Terms and Conditions

2. Figure 1
Pivotal role of p27Kip1 in the induction of hypertrophy in various renal cells. For example, high-glucose medium stimulates expression of p27Kip1 in cultured mesangial cells through the activation of protein kinase C. On the other hand, angiotensin II (Ang II)-mediated hypertrophy also depends on stimulated expression of p27Kip1, which is probably mediated by reactive oxygen species. High-glucose medium as well as Ang II also induce transforming growth factor-β, which, in turn, may also increase p27Kip1 expression. p27Kip1 interacts with cyclin-dependent kinase (CDK)-cyclin complexes and inhibits their activity. The consequence is a G1-phase arrest of cells with hypertrophy and probably an accumulation of extracellular matrix proteins.
Kidney International  , DOI: ( /j x)
Copyright © 1999 International Society of Nephrology Terms and Conditions