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Saltatory Conduction
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Voltage drop without myelin
DVx = DVoe-x/l The length constant, l, is the distance over which the potential falls by 1-1/e a reduction of 63% of the original PD at the point where current was injected. Length constants range from .1 mm for a small axon with a low resistance membrane to 5 mm for a large axon with a high resistance membrane. Size, and high resistance increase the length constant and current spread.
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Spinal Cord and CNS Injury
Problems Cell Death and Secondary death Disruption of Nerve pathways Demyelination
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Therapies Neuroprotection Growth Factors, Vitamin C,
Temperature Change Replacement of Nerve Cells Transplant of Fetal Tissue Native Stem Cells
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Regenerationn of Damaged Axons
Schwann cell transplant Use of olfactory cells Remyelination of Axons
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Post Synaptic Potential
Post Synaptic Potentials are Gradeed
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Post Synaptic Potentials can be summed temporally and spatially
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