1. Fig. 8. Esco2-dependent cis-DNA looping model underlying the etiology of RBS. (A) Schematic representation of the cohesin ring complex.
Esco2-dependent cis-DNA looping model underlying the etiology of RBS. (A) Schematic representation of the cohesin ring complex. It is composed of two structural maintenance of chromosome (SMC) subunits (SMC1A and SMC3) and three non-SMC subunits (RAD21, SA1, 2 and PDS5). The cohesin auxiliary factor, NIPBL-MAU2 heterodimer complex helps in cohesin ring opening/closing reactions that loads cohesins onto DNA. Another auxiliary factor, ESCO2, is a member of the ESCO family of N-acetyltransferases that acetylates the SMC3 cohesin subunit. (B) A model depicting the Esco2-dependent cis-DNA tethering mechanism underlying RBS in which the acetyltransferace Esco2 activates its target, Smc3 (denoted by Ac), which binds the cx43 promoter, thus activating cx43 transcription. This process is believed to occur through a cis-DNA looping mechanism that connects the enhancer (E) and promoter (P) of the cx43 gene.
Rajeswari Banerji et al. Biology Open 2017;6:
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