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Stephanie A. Shore, PhD, Raya D

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1 Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice 
Stephanie A. Shore, PhD, Raya D. Terry, BSc, Lesley Flynt, BSc, Aimin Xu, MD, Christopher Hug, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 118, Issue 2, Pages (August 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Effect of adiponectin on BAL leukocytes. Results are means ± SE of data from 4 to 20 mice in each group. ∗P < .05 versus PBS group with same treatment. #P < .05 versus OVA-challenged mice treated with TBS. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Effect of adiponectin on BALF TH2 cytokines. Mice were treated with either buffer (TBS) or adiponectin and challenged with either PBS or OVA. Results are means ± SE of data from 4 to 11 mice in each group. ∗P < .05 versus PBS group with same treatment. #P < .05 versus OVA-challenged mice treated with TBS. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Effect of adiponectin on airway responsiveness to intravenous methacholine. Mice were treated with either buffer (TBS) or adiponectin and challenged with either PBS or OVA. RL was measured by means of forced oscillation. Results are means ± SE of data from 4 to 8 mice in each group. ∗P < .05 versus PBS group with same treatment. #P < .05 versus OVA-challenged mice treated with TBS. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Effect of treatment with TBS buffer or adiponectin on serum adiponectin level (A) and adipose tissue adioponectin mRNA expression (B). Mice were challenged with either PBS or OVA. Results are means ± SE of data from 4 to 15 mice in each group. Adiponectin mRNA expression was normalized for expression of 18S rRNA. ∗P < .05 versus PBS group with same treatment. #P < .05 versus TBS treated mice with same aerosol challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

6 Fig 5 Effect of treatment with TBS buffer or adiponectin on pulmonary adipoR (A), adipoR2 (B), and T-cadherin (C) mRNA expression. Mice were challenged with either PBS or OVA. Results are means ± SE of data from 4 to 15 mice in each group. Gene expression was normalized for expression of 18S rRNA. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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