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Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma  Yasurou Kohno, MDa,

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Presentation on theme: "Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma  Yasurou Kohno, MDa,"— Presentation transcript:

1 Effect of rush immunotherapy on airway inflammation and airway hyperresponsiveness after bronchoprovocation with allergen in asthma  Yasurou Kohno, MDa, Kenji Minoguchi, MD, PhDa, Naruhito Oda, MDa, Takuya Yokoe, MDa, Naomi Yamashita, MD, PhDb, Tsuyoshi Sakane, MD, PhDb, Mitsuru Adachi, MD, PhDa  Journal of Allergy and Clinical Immunology  Volume 102, Issue 6, Pages (December 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 IL-5 production by D farinae- specific T-cell lines before and after 5 months in RIT-treated and untreated control patients. T-cell lines (5 × 105 ) were stimulated with 10 μg/mL of D farinae allergen with irradiated PBMCs (5 × 105 ) as antigen-presenting cells. Culture supernatants were harvested 16 hours later, and IL-5 was measured with ELISA. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Percentages of (A ) total eosinophils, (B ) EG2+ eosinophils, and (C ) ECP concentration in induced sputum before and after 6 months in RIT-treated and untreated control patients. Induced sputum was obtained before (baseline ) and 24 hours after allergen challenge (postallergen ). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Airway responsiveness to histamine before and after 6 months in RIT-treated and untreated control patients. PC20 was analyzed before (baseline ) and 24 hours after allergen challenge (postallergen ). Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Percent fall in FEV1 after bronchoprovocation with allergen before and after 6 months in RIT-treated and untreated control patients. At the start of the study, EAR was induced by allergen challenge in all subjects, and LAR was induced in 4 of 6 control subjects and in 6 of 8 subjects later treated with RIT. These rates of induction of EAR and LAR did not change after 6 months of treatment. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

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