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House dust mite sublingual immunotherapy: Results of a US trial

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1 House dust mite sublingual immunotherapy: Results of a US trial
Robert K. Bush, MD, Cheri Swenson, BS, Beth Fahlberg, RN, Michael D. Evans, MS, Robert Esch, PhD, William W. Busse, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 4, Pages e7 (April 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Enrollment and participation demographics, January 2006: screening of potentially eligible subjects. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 D farinae–specific IgE serum levels showed a slight but statistically nonsignificant increase from baseline values in the high-dose SLIT group. NS, Not significant. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 D farinae–specific IgG4 serum levels at baseline, 6 months, and the end of the study showed a significant increase from baseline values in the high-dose SLIT treatment group. ANCOVA, Analysis of covariance; NS, not significant. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 AgPD20 values at baseline and the end of the study were significantly increased in the high-dose SLIT treatment group. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Relationship of change in AgPD20 and serum specific IgG4 ratio (end of study vs baseline) showed a significantly positive correlation. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Schedule of evaluations. HDM, House dust mite.
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Daily antihistamine medication scores
Daily antihistamine medication scores. No significant differences were found between treatment groups. Maximum score = 5. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Albuterol use by asthmatic subjects (high-dose SLIT, n = 4; low-dose SLIT, n = 3; and placebo, n = 3). No significant differences were found between treatment groups. Maximum score = 8. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 D farinae allergen (Der f 1) content of settled dust samples showed low levels that were similar across treatment groups. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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