1. Volume 83, Issue 3, Pages 517-523 (March 2013)
Intensive glucose control improves kidney outcomes in patients with type 2 diabetes 
Vlado Perkovic, Hiddo Lambers Heerspink, John Chalmers, Mark Woodward, Min Jun, Qiang Li, Stephen MacMahon, Mark E. Cooper, Pavel Hamet, Michel Marre, Carl Erik Mogensen, Neil Poulter, Giuseppe Mancia, Alan Cass, Anushka Patel, Sophia Zoungas 
Kidney International 
Volume 83, Issue 3, Pages (March 2013)
DOI: /ki
Copyright © 2013 International Society of Nephrology Terms and Conditions

2. Figure 1
Individual renal outcomes by randomized group. Kaplan–Meier curves depicting the incidence of (a) end-stage kidney disease (ESRD), (b) renal death, (c) ESRD or renal death, and (d) doubling of creatinine to at least 200μmol/l over time by randomized group (transient or sustained). (a) End-stage renal disease. Hazard ratio for intensive versus control: 0.35, 95% confidence interval (CI) 0.15–0.83, P=0.01. (b) Renal death. Hazard ratio for intensive versus control 0.85, 95% CI 0.45–1.63, P=0.63. (c) Combined ESRD/renal death. Hazard ratio for intensive versus control: 0.64, 95% CI 0.38–1.08, P=0.09. (d) Sustained doubling of serum creatinine. Hazard ratio for intensive versus control: 0.83, 95% CI 0.54–1.27, P=0.38.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

3. Figure 2
Summary plot showing the effects of intensive glucose lowering compared with standard glucose lowering on renal outcomes. CI, confidence interval; doubling to >200, adjudicated doubling of serum creatinine to a value over 200μmol/l; sustained doubling >200, doubling of creatinine as above that remained at least doubled at the final available follow-up reading; ESRD, end-stage renal disease.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

4. Figure 3
Subgroup analyses by baseline characteristics for the outcome of end-stage renal disease. The P-value provided represents test for heterogeneity between subgroups. CI, confidence interval; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions

5. Figure 4
Serum creatinine levels during follow-up (intensive vs. standard glucose control), P=0.22. Error bars: s.e. Broken black line: intensive group. Solid green line: standard group. The color reproduction of this figure is availabe on Kidney International Journal online.
Kidney International  , DOI: ( /ki )
Copyright © 2013 International Society of Nephrology Terms and Conditions