1. Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis 
J.-y. Yan, F.-m. Tian, W.-Y. Wang, Y. Cheng, H.-P. Song, Y.-Z. Zhang, L. Zhang 
Osteoarthritis and Cartilage 
Volume 22, Issue 11, Pages (November 2014)
DOI: /j.joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Outline of the proximal tibia and histological findings of articular cartilage at distal femur by Masson staining (×200) and OARSI score of the articular cartilage in each group. A, 1 month group; B, 3 months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Immunohistochemistry assay for type-II collagen and the changes of IOD in expression. (×200) Immunohistochemical analysis showed that the protein levels of type-II collagen in control group were weaker than those in the PTH treated group. A, 1 month group; B, 3 months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group; G, negative control staining. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Immunohistochemistry assay for PTH1R in the cartilage and subchondral bone and the changes of IOD in expression. (×200) Immunohistochemical analysis showed that the protein levels of PTH1R in cartilage and subchondral bone in control group were weaker than those in the PTH treated group. A, 1 month group; B, 3 months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group; G, negative control staining. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Immunohistochemistry assay for MMP-13 and SOST and the changes of IOD in expression (×200). Immunohistochemical analysis showed that the protein levels of MMP-13 and SOST in control group were stronger than those in PTH treated group. A, 1 month group; B, 3 months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group; G, negative control staining. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
Immunohistochemistry assay for OPG in the cartilage and subchondral bone and the changes of IOD in expression. (×200) Immunohistochemical analysis showed that the protein levels of OPG in cartilage and subchondral bone in control group were weaker than those in the PTH treated group. A, 1 month group; B, 3months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group; G, negative control staining. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

7. Fig. 6
Immunohistochemistry assay for RANKL in the cartilage and subchondral bone and the changes of IOD in expression. (×200) Immunohistochemical analysis showed that the protein levels of RANKL in cartilage and subchondral bone in control group were stronger than those in the PTH treated group. A, 1 month group; B, 3 months group; C, 6 months group; D, 9 months group; E, 6 months (PTH) group; F, 9 months (PTH) group; G, negative control staining. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

8. Fig. 7
The ratio of OPG/RANKL expression in the cartilage and subchondral bone. *P < 0.05, compared with 1 month group; #P < 0.05, compared with 3 months group; &P < 0.05, compared with 6 months group; ▲P < 0.05, PTH group compared with control group.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions