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Fig. 4. Clinically defined SMN mutants show alterations in the association with telomerase complex proteins. Clinically defined SMN mutants show alterations.

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Presentation on theme: "Fig. 4. Clinically defined SMN mutants show alterations in the association with telomerase complex proteins. Clinically defined SMN mutants show alterations."— Presentation transcript:

1 Fig. 4. Clinically defined SMN mutants show alterations in the association with telomerase complex proteins. Clinically defined SMN mutants show alterations in the association with telomerase complex proteins. (A-B) Cells were transfected with wild-type (WT) or clinically defined SMN mutations, fused to GFP. IPs were performed using anti-GFP antibody. The resulting immunocomplexes were then probed for either dyskerin (A) or NAF1 (B). (C) Graphical representation of the data shown in (A) and (B) (n=8), normalized to the recovery of dyskerin and NAF1 by WT SMN. *P<0.05 compared to WT SMN, which serves as a control. Error bars represent standard error about the mean. For all IPs, inputs represent 1.5% the amount of the lysate used in the IP reaction. Note that GFP vector alone does not recover significant amounts of dyskerin (Fig. 2B, lane 5). Aaron R. Poole, and Michael D. Hebert Biology Open 2016;bio © Published by The Company of Biologists Ltd

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