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International Journal of Cardiology

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Presentation on theme: "International Journal of Cardiology"— Presentation transcript:

1 International Journal of Cardiology
Prediction of absolute risk reduction of cardiovascular events with perindopril for individual patients with stable coronary artery disease — Results from EUROPA  Joep van der Leeuw, Rohit M. Oemrawsingh, Yolanda van der Graaf, Jasper J. Brugts, Jaap W. Deckers, Michel Bertrand, Kim Fox, Roberto Ferrari, Willem J. Remme, Maarten L. Simoons, Eric Boersma, Frank L.J. Visseren  International Journal of Cardiology  Volume 182, Pages (March 2015) DOI: /j.ijcard Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Calibration plots of predicted versus observed 4.3year absolute risk reduction (ARR) of major cardiovascular events (MACE) in quintiles for different prediction scores. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Distribution of 5-year absolute risk reduction (ARR) of major cardiovascular events with perindopril treatment for individual patients with stable CAD. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Net benefit curves of different treatment strategies for major cardiovascular events (MACE). Net benefit is calculated as the observed ARR of MACE (%) in patients whose randomized allocation is similar to recommendations from the treatment score minus the disadvantages of treatment. The disadvantages of treatment are expressed as the proportion of patients receiving treatment weighted by the threshold NNT. First, a (range of) threshold NNT should be determined and next the strategy associated with the highest net benefit for this (range of) threshold can be extracted from the graph. The threshold NNT may vary among clinicians and patients. The treat all line originates at the average ARR observed in the trial, since the negative effects of treatment are assumed to be zero at an infinite threshold NNT5. Treat none is associated with zero net benefit. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

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