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Volume 124, Issue 5, Pages (May 2003)

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Presentation on theme: "Volume 124, Issue 5, Pages (May 2003)"— Presentation transcript:

1 Volume 124, Issue 5, Pages 1311-1314 (May 2003)
Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability  Pierre Laurent-puig, Olivier Plomteux, Olivier Bluteau, Franck Zinzindohoué, Emmanuelle Jeannot, Karin Dahan, Alex Kartheuser, Caroline Chapusot, Paul-henri Cugnenc, Jessica Zucman-rossi  Gastroenterology  Volume 124, Issue 5, Pages (May 2003) DOI: /S (03)

2 Figure 1 Exon 4 sequence electrophoregram. (A) Forward; (B) reverse. 106T nonmutated sequence showing polymorphism G → C at nucleotide 864, codon 288; 2T showing a deletion of one C at nucleotide 872 in (C)9 allele. 8T showing ins C at nucleotide 872 in (C)8 allele; 121T showing a deletion of one C at nucleotide 872 in (C)8 allele. Gastroenterology  , DOI: ( /S (03) )

3 Figure 2 Frequency of HNF1 864 G → C genotype in exon 4 according to tumor phenotype MSI-H or loss of heterozygosity. Gastroenterology  , DOI: ( /S (03) )


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