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EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers

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Presentation on theme: "EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers"— Presentation transcript:

1 EGFR Mutations in Squamous Cell Lung Cancer in Never-Smokers
Christina S. Baik, MD, MPH, Colin C. Pritchard, MD, PhD, Keith D. Eaton, MD, PhD, Laura Q. Chow, MD  Journal of Thoracic Oncology  Volume 8, Issue 1, Pages e6-e7 (January 2013) DOI: /JTO.0b013e d49 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Representative hematoxylin and eosin stained sections of SCC and ADC tumors from each case. A, Case 1: epidural mass (SCC), (B) case 1: pericardial fluid (ADC), (C) case 2: supraclavicular mass (SCC), and (D) case 2: pleural fluid (ADC). SCC, squamous cell carcinoma; ADC, adenocarcinoma. Journal of Thoracic Oncology 2013 8, e6-e7DOI: ( /JTO.0b013e d49) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Molecular testing results. A, An EGFR L858R mutation was identified in the SCC in patient 1 by melting curve analysis with a mutation-specific probe (black trace, small peak at ~63°C). B, A 15-base pair EGFR exon 19 deletion was identified in the SCC of patient 2 by capillary electrophoresis (peaks at ~102 base pair). Adenocarcinoma lesions from each patient shared the same EGFR mutation as the SCC component (data not shown). SCC, squamous cell carcinoma. Journal of Thoracic Oncology 2013 8, e6-e7DOI: ( /JTO.0b013e d49) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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