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Differential action of angiotensin II and activity of angiotensin-converting enzyme in human bypass grafts Julie A. Borland, BSca, Adrian H. Chester, PhDa, Simon Crabbe, PhDa, James B. Parkerson, BScb, John D. Catravas, PhDb, Magdi H. Yacoub, MD, FRCSa The Journal of Thoracic and Cardiovascular Surgery Volume 116, Issue 2, Pages (August 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 1 Measurements of ACE activity in human SVs (n = 25), ITAs (n = 27), and old SVs (n = 16). Values are means ± standard error of the mean. **p < in the SV and old SV when compared with the ITA. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 2 Contractile effect of angiotensin II in isolated segments of SV (■, n = 18), ITA (●, n = 16), and old SV (▴, n = 9) bypass grafts. Values are means ± standard error of the mean. *p = in the SV when compared with the ITA and p = 0.03 in the SV compared with the old SV graft. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 3 Contractile effect of angiotensin II in the absence (■, n = 6) and the presence of 10–4 mol/L l-NMMA (●, n = 6), 10–5 mol/L bosentan (▴, n = 6), or 10–6 mol/L indomethacin (☆, n = 6) in either (A) isolated segments of SV or (B) isolated segments of ITA. Values are means ± standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 4 Photomicrographs of cross sections of (A) SV, (B) old SV graft, and (C) ITA, showing positive staining for eNOS (arrows). Scale bar represents 100 μm. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 5 Contractile effect of angiotensin II in the absence (■, n = 7) and the presence of 10–8 mol/L (●, n = 7), 10–7 mol/L (▴, n = 7), or 10–6 mol/L (☆, n = 7) of either (A) losartan or (B) PD in isolated segments of SV. Values are means ± standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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Fig. 6 Contractile effect of angiotensin II in the absence (■, n = 4) and the presence of 10–8 mol/L (●, n = 4), 10–7 mol/L (▴, n = 4), or 10–6 mol/L (☆, n = 4) of either (A) losartan or (B) PD in isolated segments of ITA. Values are means ± standard error of the mean. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions
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