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Aberrant development of the anterior segment in AP-2β NCC KO mutants.

Published byElli Kouki Modified over 5 years ago

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Presentation on theme: "Aberrant development of the anterior segment in AP-2β NCC KO mutants."— Presentation transcript:

1 Aberrant development of the anterior segment in AP-2β NCC KO mutants.
Aberrant development of the anterior segment in AP-2β NCC KO mutants. H&E-stained coronal or sagittal sections of E10.5 (A,B), E15.5 (C,D) and 2- to 3-month-old (E-H) control littermates (A,C,E,G) and AP-2β NCC KO samples (B,D,F,H). In D arrowheads indicate the juxtaposition of the cornea and lens compared to control littermates. In F, the blue arrow indicates a closed angle with adherence between the iris and cornea and the blue circle shows hypoplastic ciliary body. In H, the white asterisk indicates the location of the anterior subcapsular cataracts and also note adherence of lens and cornea, as well as thinner corneal epithelium. Immunofluorescent detection of N-cadherin in 2- to 3-month-old sagittal sections of control littermate (I) and an AP-2β NCC KO mutant (J). In J, the asterisk indicates the absence of corneal endothelium staining and the large white arrow points to the subcapsular cataract region of the lens. CB, ciliary body; CEn, corneal endothelium; CEp, corneal epithelium; CS, corneal stroma; dR, developing retina; IC, iridocorneal angle; LEp, lens epithelium; LV, lens vesicle; OC, optic cup; POM, periocular mesenchyme. Scale bars: 100 μm. Vanessa B. Martino et al. Dis. Model. Mech. 2016;9: © Published by The Company of Biologists Ltd

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