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Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid Jean-Christophe Lousse, M.D., Sylvie Defrère, Ph.D., Anne Van Langendonckt, Ph.D., Jérémie Gras, M.D., Reinaldo González-Ramos, M.D., Ph.D., Sébastien Colette, M.Sc., Jacques Donnez, M.D., Ph.D. Fertility and Sterility Volume 91, Issue 5, Pages (May 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Ferritin immunocytochemical staining on isolated peritoneal macrophages fixed in formol and projected onto slides. Original magnification ×200. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Optical density of (A) peritoneal macrophage ferritin immunocytochemical staining, (B) peritoneal iron concentration, (C) peritoneal transferrin saturation, and (D) peritoneal ferritin concentration according to the presence or absence of endometriosis. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions
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Figure 3 Iron metabolism by peritoneal macrophages. Macrophages acquire most of their iron by phagocytosing red blood cells or endocytosing the hemoglobin–haptoglobin complex. Proteolytic digestion of hemoglobin liberates heme, which is catabolized by heme oxygenase (HO) to produce reactive iron. The free iron released is then incorporated into macrophage ferritin or returned to the iron transporter transferrin in peritoneal fluid. Hepcidin may regulate iron metabolism by macrophages via inhibiting iron efflux through ferroportin (FPN). Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions
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