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Joaquim Mullol, MD, Joan C

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1 Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps 
Joaquim Mullol, MD, Joan C. Fernàndez-Morata, MS, Jordi Roca-Ferrer, MS, Laura Pujols, MS, Antoni Xaubet, MD, Pedro Benitez, MD, Cesar Picado, MD  Journal of Allergy and Clinical Immunology  Volume 109, Issue 5, Pages (May 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Spontaneous expression of genes encoding for Cox-1 and Cox-2 in NM (n = 7) and NPs (n = 11). *P < .05 compared with the time of the operation (0 hours) and †P < .05 compared with NPs (Wilcoxon signed-rank test). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 Spontaneous protein expression of Cox-1 and Cox-2 in NPs (n = 4). *P < .05 compared with the time of the operation (0 hour; Wilcoxon signed-rank test). Insets show representative experiments of Cox-1 (70 kd) and Cox-2 (74 kd) spontaneous protein expression in NPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

4 Fig. 3 Time-dependent regulation of Cox-1 and Cox-2 mRNA expression by a mixture of proinflammatory cytokines (Cyt Mix ; IFN-γ, IL-1β, and TNF-α, 1 ng/mL) in explants from NM (n = 7) and NPs (n = 11). *P < .05 compared with culture media and †P < .05 compared with NPs (Wilcoxon signed-rank test). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

5 Fig. 4 Dose-related effects of proinflammatory cytokine mixture (Cyt Mix ; IFN-γ, IL-1β, and TNF-α, ng/mL) on Cox-2 mRNA expression (1 hour) in explants from NM (n = 6) and NPs (n = 6). *P < .05 compared with culture media (C ; Mann-Whitney U test). Insets show representative experiments of Cox-2 mRNA expression in both NM and NPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

6 Fig. 5 Dose-related effects of proinflammatory cytokine mixture (Cyt Mix , IFN-γ, IL-1β, and TNF-α, ng/mL) on Cox-2 mRNA and protein expression (24 hours) in NPs. *P < .05 compared with culture media (C ; Mann-Whitney U test). Insets show representative experiments of cytokine-induced Cox-2 mRNA and protein expression in NPs. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

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