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No significant functional difference could be observed between N1ICD and N2ICD in maintaining skin barrier function and promoting tumorigenesis. No significant.

Published byMartyna Sikora Modified over 5 years ago

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Presentation on theme: "No significant functional difference could be observed between N1ICD and N2ICD in maintaining skin barrier function and promoting tumorigenesis. No significant."— Presentation transcript:

1 No significant functional difference could be observed between N1ICD and N2ICD in maintaining skin barrier function and promoting tumorigenesis. No significant functional difference could be observed between N1ICD and N2ICD in maintaining skin barrier function and promoting tumorigenesis. (A,B) The loss of the ICD from Notch1 locus, but not from Notch2 locus, disrupts the normal skin barrier function and leads to increased TSLP production and WBC count (A) as well as an obvious skin phenotype (B); the presence of ICD1 or ICD2 in the Notch1 locus, but not Notch2 locus, restores the normal skin barrier function (A,B). ND, not determined; N.S., not statistically significant. (C-E) The presence of N1ICD under the control of the N2 locus could not prevent animals that lost wild-type Notch1 from developing carcinomas after DMBA treatment. Error bars represent s.d. *P<0.05. Zhenyi Liu et al. Development 2015;142: © Published by The Company of Biologists Ltd

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