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Extrathymic T-lymphocyte development

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Presentation on theme: "Extrathymic T-lymphocyte development"— Presentation transcript:

1 Extrathymic T-lymphocyte development
Marie-Ève Blais, Isabelle Louis, Sophie Corneau, Gwladys Gérard, Rafik Terra, Claude Perreault  Experimental Hematology  Volume 31, Issue 5, Pages (May 2003) DOI: /S X(03)

2 Figure 1 Massive extrathymic T-cell development in the lymph nodes of oncostatin M (OM)-transgenic mice. Morphology and T lymphocyte subsets of the mesenteric lymph node from an OM-transgenic mouse and lymphoid organs (thymus and mesenteric lymph node) from a nontransgenic littermate. Lymphoid cells were stained with antibodies against CD4 and CD8. Experimental Hematology  , DOI: ( /S X(03) )

3 Figure 2 Schematic overview of normal T-cell development and proposed pathway for extrathymic T-cell development in OM-transgenic mice (see text). DN, double-negative T cells; DP, double-positive T cells; HEV, high endothelial venules; HSC, hematopoietic stem cell; LN, lymph node; OM, oncostatin M; SP, single-positive T cell. Experimental Hematology  , DOI: ( /S X(03) )


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