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Fig. 8. The cohort of 3KO/CCS-LacZ embryos that survived to later timepoints showed marked hyperplasia of the ventricular conduction system (A–F).(B) Severe enlargement of the His bundle and left bundle branch resulted in LVOT obstruction. The cohort of 3KO/CCS-LacZ embryos that survived to later timepoints showed marked hyperplasia of the ventricular conduction system (A–F).(B) Severe enlargement of the His bundle and left bundle branch resulted in LVOT obstruction. (D) The right bundle branch and Purkinje network were markedly hyperplastic and thickened. (F) A higher magnification and over-exposure of the right bundle branch and Purkinje fibers demonstrated equilibration of nuclear densities between the VCS/trabecular myocytes and the compact myocardium. Scale bars: 200 µm. David S. Park et al. Biology Open 2013;bio © Published by The Company of Biologists Ltd
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