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TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced.

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Presentation on theme: "TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced."— Presentation transcript:

1 TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced late-phase cutaneous reaction  Sun Ying, MD, PhDa, Yoko Kikuchi, DVM, MPVMb, Qiu Meng, MDa, A.Barry Kay, FRCP, PhDa, Allen P. Kaplan, MDb  Journal of Allergy and Clinical Immunology  Volume 109, Issue 4, Pages (April 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Congo red–positive eosinophils, elastase-positive neutrophils, BB1+ basophils, CD68+ macrophages, and tryptase-positive mast cells in skin biopsy specimens from healthy, nonatopic control subjects (open columns , n = 6; top ) and patients with CIU (filled columns , n = 13; top ) and diluent challenge sites (open columns , n = 6; bottom ) and allergen-induced skin LPR (filled columns , n = 6; bottom ). The results are expressed as the numbers of positive cells per square milliliter of biopsy specimen. The differences between patients with CIU and healthy, control subjects or allergen-induced skin LPR sites and diluent-challenged control sites were analyzed by using the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 The numbers of CD3+, CD4+, CD8+, and CD25+ T cells in skin biopsy specimens from healthy, nonatopic control subjects (open columns , n = 6; top ) and patients with CIU (filled columns , n = 13; top ) and diluent challenge sites (open columns , n = 6; bottom ) and allergen-induced skin LPR sites (filled columns , n = 6; bottom ). The results are expressed as the numbers of positive cells per square milliliter of biopsy specimens. The differences between patients with CIU and healthy, control subjects or allergen-induced skin LPR sites and diluent-challenged control sites were analyzed by means of the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

4 Fig. 3 Infiltrating CD3+, CD4+, and CD8+ T cells in epidermis of skin biopsy specimens from healthy, nonatopic control subjects (open circles , n = 6), patients with CIU (filled circles , n = 13), diluent challenge sites (open squares , n = 6), and allergen-induced skin LPR sites (filled squares , n = 6). The results are expressed as the numbers of positive cells per milliliter of skin epidermis. The differences between patients with CIU and healthy control subjects or allergen-challenged skin LPR sites and diluent-challenged control sites were analyzed by means of the Mann-Whitney U test. NC , Nonatopic control subject; Dil , diluent-challenged skin sites; Ag , antigen-challenged skin LPR sites. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

5 Fig. 4 The numbers of cells expressing mRNA for IL-4, IL-5, and IFN-γ in skin biopsy specimens from healthy, nonatopic control subjects (open columns , n = 6; top ) and patients with CIU (filled columns , n = 13; top ) and diluent challenge sites (open columns , n = 6; bottom ) and allergen-induced skin LPR sites (filled columns , n = 6; bottom ). The results are expressed as the numbers of positive cells per square milliliter of biopsy specimen. The differences between patients with CIU and healthy control subjects or allergen-challenged skin LPR sites and diluent-challenged control sites were analyzed by means of the Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

6 Fig. 5 CD3+ T cells (A) , Congo red–positive eosinophils (B) , elastase-positive neutrophils (C) , and CD68+ macrophages (D) in skin biopsy specimens from patients with CIU. Positive cells are stained red (arrows) . Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

7 Fig. 6 A , CD3+ T cells (arrows) in epidermis and dermis in patients with CIU. B , CD3+ T cells in the dermis only in allergen-induced skin LPR sites. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

8 Fig. 7 IL-4 and IL-5 mRNA+ cells in skin biopsy specimens from allergen-challenged LPR sites and patients with CIU. Positive hybridization with 35S-labeled IL-4 (A) and IL-5 (B) antisense riboprobes (arrows) from a biopsy specimen taken 24 hours after allergen challenge. Positive hybridization signals for IL-4 (C) and IL-5 (D , arrows ) from a biopsy specimen from patients with CIU. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

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