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Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris  Takashi Kakinuma, MDa,

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Presentation on theme: "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris  Takashi Kakinuma, MDa,"— Presentation transcript:

1 Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris  Takashi Kakinuma, MDa, Hidehisa Saeki, MDa, Yuichiro Tsunemi, MDa, Hideki Fujita, MDa, Noriko Asano, MDa, Hiroshi Mitsui, MDa, Yayoi Tada, MDa, Motoshi Wakugawa, MDa, Takahiro Watanabe, MDa, Hideshi Torii, MDa, Mayumi Komine, MDa, Akihiko Asahina, MDa, Koichiro Nakamura, MDb, Kunihiko Tamaki, MDa  Journal of Allergy and Clinical Immunology  Volume 111, Issue 3, Pages (March 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 A, Serum CTACK levels in patients with AD (n = 50), patients with PsV (n = 30), and healthy control subjects (HC ; n = 22). B, Serum CTACK levels in patients with AD (n = 10) were evaluated before and after treatment. C, Comparison of serum CTACK levels among healthy control subjects and 3 groups of patients with AD: Those with mild (n = 10), moderate (n = 24), and severe disease (n = 16). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 CTACK was strongly expressed in the lesional keratinocytes of patients with AD (a) and PsV (b) . In contrast, it was moderately expressed in the basal layer of the normal skin of healthy control subjects (c) . When an isotype-matched control was used, no reactivity was observed (d ; original magnification: 200×). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 IP-10 was focally expressed in the lesional keratinocytes of patients with AD (a) , whereas it was strongly expressed in those with PsV (b) . When an isotype-matched control was used, no reactivity was observed (data not shown; original magnification: 100×). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions


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