1. Volume 82, Issue 6, Pages 619-620 (September 2012)
Targeting activated mineralocorticoid receptor: Occam's razor revisited 
Andrew S. Brem 
Kidney International 
Volume 82, Issue 6, Pages (September 2012)
DOI: /ki
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2. Figure 1
MR selectivity for activation appears to be tissue dependent. Both vascular and renal tissue MRs respond to aldosterone, but the MR activation in vascular tissue by endogenous glucocorticoids such as cortisol or corticosterone is more related to the presence of reactive oxygen species (oxidized glutathione) and is less regulated by 11β-HSD. In the kidney, the activity of both renal 11β-HSD isoforms clearly determines whether or not MR is activated by endogenous glucocorticoids. 11β-HSD, 11β-hydroxysteroid dehydrogenase; MR, mineralocorticoid receptor.
Kidney International  , DOI: ( /ki )
Copyright © 2012 International Society of Nephrology Terms and Conditions