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Genetic Syndromes and Outcome After Surgical Repair of Pulmonary Atresia and Ventricular Septal Defect  Meng-Yu Chen, MD, Shuenn-Nan Chiu, MD, PhD, Jou-Kou.

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Presentation on theme: "Genetic Syndromes and Outcome After Surgical Repair of Pulmonary Atresia and Ventricular Septal Defect  Meng-Yu Chen, MD, Shuenn-Nan Chiu, MD, PhD, Jou-Kou."— Presentation transcript:

1 Genetic Syndromes and Outcome After Surgical Repair of Pulmonary Atresia and Ventricular Septal Defect  Meng-Yu Chen, MD, Shuenn-Nan Chiu, MD, PhD, Jou-Kou Wang, MD, PhD, Chun-Wei Lu, MD, Ming-Tai Lin, MD, PhD, Chung-I. Chang, MD, Ing-Sh Chiu, MD, PhD, Yih-Sharng Chen, MD, PhD, Shyh-Jye Chen, MD, PhD, Mei-Hwan Wu, MD, PhD  The Annals of Thoracic Surgery  Volume 94, Issue 5, Pages (November 2012) DOI: /j.athoracsur Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Overall survival after repair in 125 patients with pulmonary atresia and ventricular septal defect. There were 24 deaths after repair, 12 deaths in early phase after operation, and 12 deaths in later follow-up. The 10- and 20-year survival rates were 81% and 74%, respectively. Numbers at bottom represent the number of patients followed up at that point. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Survival after repair stratified by types of genetic syndromes. There was a statistically significant difference among 3 subgroups (p < 0.01). The 10-year survival was 90% in patients without syndromes, 67% in patients with 22q11 deletion (del22q11) syndrome, and 25% in patients with other syndromes. The solid line indicates those patients without genetic syndromes; the dashed line, those with del22q11 syndromes; and the dash-dot line, those with genetic syndromes other than del22q11. Numbers at bottom represent the number of patients followed up at that point. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

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