1. DES alters uterine gene expression primarily in the epithelium.
DES alters uterine gene expression primarily in the epithelium. (A) Hierarchical clustering heatmap of differentially regulated genes by DES in the UE and UM. Green to red, color range gradient of mean abundance (−0.7 to 0.7). Each column represents a pool of more than three animals. Red box, genes whose expression was altered by DES primarily in the UE; green box, genes regulated by DES similarly in the UE and UM; black box, genes altered by DES primarily in the UM. (B) Star glyph distribution of the fold-change of differentially regulated gene in the uterus; log2 values of the mean fold-change. Red, UM; blue, UE. (C) Venn diagram of UE and UM DRGs. (D) Pie chart showing classification of DRGs based on Gene Ontology Consortium biological processes. Note that some genes might have multiple functions and could be represented in more than one category.
Yan Yin et al. Dis. Model. Mech. 2012;5:
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