1. LINKING GENE PATHWAYS AND BRAIN ATROPHY IN ALZHEIMER'S DISEASE
Marco Lorenzi, Boris A. Gutman, Andre Altmann, Derrek P. Hibar, Neda Jahanshad, Daniel C. Alexander, Paul M. Thompson, Sebastien Ourselin 
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 
Volume 12, Issue 7, Pages P6-P7 (July 2016)
DOI: /j.jalz
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2. Figure 1 Modelled phenotype component
The colour indicates the probability of maximal correlation between cortical thiskness loci and genotype variation. At the cortical level, the involved areas are the temporal and the parahippocampal cortex, as well as the posterior cingulum. At the subcortical level, the involved areas are the posterior hippocampi, amygdalae (frontal part), thalami and putamen.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P6-P7DOI: ( /j.jalz )
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3. Figure 2 Modelled genotype component
The circular Manhattan plot shows the probability of a given genetic locus to be maximally correlated with the cortical thickness variation (Figure 1). The genes proximal to the significant loci are listed in the inner radial list, depending on their physical position.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P6-P7DOI: ( /j.jalz )
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4. Figure 3
Pathways analysis on the set of 389 genes identified by the model
The table shows the significant terms obtained from the pathway analysis (multiple comparison corrected). The used ontologies were: Gene Ontology term, KEGG pathway, Reactome, TRANSFAC motif term, and miRBase microRNAs. The analysis was performed with the g:Profiler software (
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P6-P7DOI: ( /j.jalz )
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5. Figure 4 Testing the model on the independent MCI cohort
When independently tested on the MCI cohort, the survival analysis shows that the individual projections of the modelled genetic component are significantly associated with pathological markers (time to conversion, MMSE, and hippocampal volume)
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  , P6-P7DOI: ( /j.jalz )
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