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Volume 76, Issue 12, Pages (December 2009)

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Presentation on theme: "Volume 76, Issue 12, Pages (December 2009)"— Presentation transcript:

1 Volume 76, Issue 12, Pages 1223-1224 (December 2009)
Protein kinase Cζ: not-so-innocent bystander or unusual suspect in kidney transplant rejection?  Jens W.D. Goebel  Kidney International  Volume 76, Issue 12, Pages (December 2009) DOI: /ki Copyright © 2009 International Society of Nephrology Terms and Conditions

2 Figure 1 Possible roles for PKCζ (yellow triangles) and antibodies against it (blue Ys) in kidney transplant rejection. Top: Donor PKCζ in the graft could become exposed as an antigenic target if inflammatory events during a rejection episode significantly impair tissue integrity. Bottom: Recipient PKCζ, after translocating into lipid rafts (curved blue disks) during immune activation, becomes accessible to potentially activating anti-PKCζ antibodies, providing a possible mechanism for amplification of the rejection response. Kidney International  , DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions


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