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Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation  Mario Leutert,

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Presentation on theme: "Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation  Mario Leutert,"— Presentation transcript:

1 Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation  Mario Leutert, Deena M. Leslie Pedrioli, Michael O. Hottiger  Molecular Cell  Volume 63, Issue 2, Pages (July 2016) DOI: /j.molcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 A Chemical Genetic Approach for Mapping PARP-Specific ADP-Riboslyated Protein Targets across the Proteome and Genome (A) Proteomic workflow. (B) Click-ChIP-seq workflow. (C) Overlap between asPARP-1, asPARP-2, and asPARP-3 protein targets, and overlap between protein targets identified by Gibson et al. (2016), Jungmichel et al. (2013), and (Zhang et al., 2013). Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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