1. Volume 131, Issue 4, Pages 1262-1270 (October 2006)
A Tumor Progression Model for Hepatocellular Carcinoma: Bioinformatic Analysis of Genomic Data 
Terence C.W. Poon, Nathalie Wong, Paul B.S. Lai, Magnus Rattray, Philip J. Johnson, Joseph J.Y. Sung 
Gastroenterology 
Volume 131, Issue 4, Pages (October 2006)
DOI: /j.gastro
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

2. Figure 1
An evolution tree for classifying the 158 HCC cases into 4 classes at 3 different evolution levels was constructed from the significant CGH events by SOTA. The class closest to the root was assigned as SOTA 1, and the 1 in the middle as SOTA 2. There were 2 classes at the bottom taxonomy level, which were grouped as SOTA 3. There were 2 subgroups A and B in the SOTA 3.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

3. Figure 2
Recurrence-free survival analysis of the HCC patients classified by SOTA. Among the 112 HCC patients who received curative tumor resection, the SOTA 3A group had a poorer recurrence-free survival compared to the SOTA 1, SOTA 2, and SOTA 3B groups.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

4. Figure 3
The frequency patterns of minimal overlapping regions of the CGH events in the 3 SOTA groups 1, 2 and 3, that potentially represent early (A), intermediate (B), and late-stage (C) events.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

5. Figure 4
Hierarchical clustering of the CGH events of SOTA 2 (A) and SOTA 3 (B). *The predicted earlier event(s) that demonstrated the highest occurrence frequency in each branch.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

6. Figure 5
Proposed evolutionary changes in the HCC carcinogenetic pathway. For chromosomal imbalances in the intermediate and late tumor stage, the minimal overlapping regions are presented.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

7. Figure 6
Overall survival (A) and recurrence-free survival (B) analyses of the HCC patients with and without gain of 3q22-24.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions