1. Journal of Cystic Fibrosis
CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials 
Scott C. Bell, Peter J. Barry, Kris De Boeck, Pavel Drevinek, J. Stuart Elborn, Barry J. Plant, Predag Minić, Eva Van Braeckel, Stijn Verhulst, Karine Muller, Desirée Kanters, Susan Bellaire, Herman de Kock, David E. Geller, Katja Conrath, Olivier Van de Steen, Kors van der Ent 
Journal of Cystic Fibrosis 
DOI: /j.jcf
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2. Fig. 1
Subject disposition for (A) the FLAMINGO study and (B) the ALBATROSS study.
*One subject, who was randomized to the placebo treatment group, received the wrong study drug kit containing the GLPG  mg q.d. doses and discontinued treatment upon sponsor's decision. The subject was not included in the modified intent-to-treat population.
q.d., quaque die (once daily).
Journal of Cystic Fibrosis DOI: ( /j.jcf )
Copyright © 2019 The Authors Terms and Conditions

3. Fig. 2
Mean (±SE) change in sweat chloride concentration from baseline to days 15 and 29 using the mean value from both arms in (A) the FLAMINGO study (ITT, LOCF) and (B) the ALBATROSS study (modified ITT, LOCF).
*p < 0.05 (treatment group versus placebo).
FLAMINGO: Pooled placebo, n = 11; GLPG  mg, n = 10; GLPG  mg, n = 10; GLPG  mg, n = 14; GLPG  mg, n = 14.
ALBATROSS: Placebo, n = 7; GLPG  mg, n = 15; GLPG  mg, n = 14.
ITT, intent-to-treat; LOCF, last observation carried over; SE, standard error.
Journal of Cystic Fibrosis DOI: ( /j.jcf )
Copyright © 2019 The Authors Terms and Conditions

4. Fig. 3
Mean (±SE) change in ppFEV1 from baseline to days 15 and 29 in (A) the FLAMINGO study (ITT, LOCF) and (B) the ALBATROSS study (modified ITT, LOCF).
FLAMINGO: Pooled placebo, n = 11; GLPG  mg, n = 10; GLPG  mg, n = 10; GLPG  mg, n = 14; GLPG  mg, n = 14.
ALBATROSS: Placebo, n = 7; GLPG  mg, n = 15; GLPG  mg, n = 14.
ITT, intent-to-treat; LOCF, last observation carried over; ppFEV1, percent predicted forced expiratory volume in one second; SE, standard error.
Journal of Cystic Fibrosis DOI: ( /j.jcf )
Copyright © 2019 The Authors Terms and Conditions