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Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation.

Published byΔήλια Μαλαξός Modified over 5 years ago

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Presentation on theme: "Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation."— Presentation transcript:

1 Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Cells were treated with 10 μM Wnt/β-catenin signaling pathway inhibitor, XAV939 for 24 h. (A) XAV939 treatment significantly inhibited the growth of A549 and SPC-A-1 cells compared with control group. (B) XAV939 treatment significantly induced apoptosis in A549 and SPC-A-1 cells compared with control group. (C) The expression levels of β-catenin, c-myc, c-met, and cyclinD1 were markedly down-regulated in XAV939-treated cells compared with control group. β-actin was used as a loading control. Mean±s.d.; *P<0.05 and **P<0.01 compared to control group. Dapeng Wu et al. Biology Open 2016;bio © Published by The Company of Biologists Ltd

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