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Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis  Henrik Källberg, Leonid Padyukov,

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Presentation on theme: "Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis  Henrik Källberg, Leonid Padyukov,"— Presentation transcript:

1 Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis  Henrik Källberg, Leonid Padyukov, Robert M. Plenge, Johan Rönnelid, Peter K. Gregersen, Annette H.M. van der Helm-van Mil, Rene E.M. Toes, Tom W. Huizinga, Lars Klareskog, Lars Alfredsson  The American Journal of Human Genetics  Volume 80, Issue 5, Pages (May 2007) DOI: /516736 Copyright © 2007 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Histograms on ORs for developing anti-CCP–positive (A) and anti-CCP–negative (B) RA for different combinations of absence or presence of R620W PTPN22, single or double HLA-DRB1 SE alleles, and smoking (based on the EIRA study). The American Journal of Human Genetics  , DOI: ( /516736) Copyright © 2007 The American Society of Human Genetics Terms and Conditions


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