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Interactive effect of family history and environmental factors on respiratory tract–related morbidity in infancy  Sandra Kuiper, PhD, Jean W.M. Muris,

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Presentation on theme: "Interactive effect of family history and environmental factors on respiratory tract–related morbidity in infancy  Sandra Kuiper, PhD, Jean W.M. Muris,"— Presentation transcript:

1 Interactive effect of family history and environmental factors on respiratory tract–related morbidity in infancy  Sandra Kuiper, PhD, Jean W.M. Muris, MD, PhD, Edward Dompeling, MD, PhD, Arnold D.M. Kester, PhD, Geertjan Wesseling, MD, PhD, J. André Knottnerus, MD, PhD, Constant P. van Schayck, PhD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 2, Pages (August 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Wheezing ever. Effect of family history on wheezing ever in infants (not) exposed to Der p 1 and PPS. 95% CI (Der p 1 < 2000/PPS no), ; 95% CI (Der p 1 < 2000/PPS yes), ; 95% CI (Der p 1 ≥ 2000/PPS no), ; 95% CI (Der p 1 ≥ 2000/PPS yes), Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Attacks of wheezing. Effect of family history on attacks of wheezing in infants (not) exposed to Der p 1 and PPS. 95% CI (Der p 1 < 2000/PPS no), 1.2–4.1; 95% CI, (Der p 1 < 2000/PPS yes), ; 95% CI (Der p 1 ≥ 2000/PPS no), ; 95% CI Der p 1 ≥ 2000/PPS yes), Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Effect of family history on parentally reported tonsillitis and otitis media, as well as GP-registered acute otitis media, in infants who were breast-fed or received formula feeding. No BF, Exclusively formula feeding; BF, breast-feeding. Tonsillitis: 95% CI (No BF), 2.1–39.7; 95% CI (BF yes), 0.8–3.8. Parentally reported otitis media: 95% CI (No BF), 1.3–9.4; 95% CI, (BF yes), 0.6–2.0. GP-registered acute otitis media: 95% CI (No BF), 1.1–7.2; 95% CI (BF yes), Adjusted for other reported risk factors. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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