1. The Fallopian Tube as the Origin of High Grade Serous Ovarian Cancer: Review of a Paradigm Shift 
Clare J. Reade, MD, MSc, Ruaidhrí M. McVey, MRCOG, MSc, Alicia A. Tone, PhD, Sarah J. Finlayson, MD, Jessica N McAlpine, MD, Michael Fung-Kee-Fung, MD, MBA, Sarah E. Ferguson, MD 
Journal of Obstetrics and Gynaecology Canada  
Volume 36, Issue 2, Pages (February 2014)
DOI: /S (15)
Copyright © 2014 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions

2. The rate of accumulation of mutations may be influenced by retrograde menstruation, with passage of menstrual blood containing inflammatory cytokines along the tubal epithelium, by damage and repair caused by ovulation, by the presence of infectious agents or irritants, or by loss or absence of DNA damage repair genes such as BRCA-1 or 2.
Journal of Obstetrics and Gynaecology Canada   , DOI: ( /S (15) )
Copyright © 2014 Society of Obstetricians and Gynaecologists of Canada Terms and Conditions