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Errol C Friedberg, Valerie L Gerlach  Cell 

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Presentation on theme: "Errol C Friedberg, Valerie L Gerlach  Cell "— Presentation transcript:

1 Novel DNA Polymerases Offer Clues to the Molecular Basis of Mutagenesis 
Errol C Friedberg, Valerie L Gerlach  Cell  Volume 98, Issue 4, Pages (August 1999) DOI: /S (00)

2 Figure 1 Schematic Representation of Proteins Involved in Error-Prone Replicative Bypass during DNA Damage-Induced (Targeted) Mutagenesis and Spontaneous (Untargeted) Mutagenesis in E. coli and S. cerevisiae Proteins with known DNA polymerase activity are shown in orange. (A) Damage-induced SOS-dependent mutagenic bypass of DNA lesions (black triangle) in E. coli involves DNA polymerase III holoenzyme, activated RecA protein, and the UmuD′2C complex. The UmuD′2C complex alone is designated as DNA polymerase V of E. coli. (B) Mutagenic bypass of UV radiation–induced lesions (black triangle) in S. cerevisiae involves Rev1 protein (also referred to as deoxycytidyl transferase), the Rev3/Rev7 complex (DNA pol ζ), Rad30 protein (DNA pol η), as well as Rad6, Rad18, RadH, and Rev2 proteins. (C) SOS-induced untargeted mutagenesis in E. coli involves DinB protein (DNA polymerase IV). Cell  , DOI: ( /S (00) )


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