1. Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong
MYOPIC CHOROIDAL
NEOVASCULARISATION
*A review of the natural history and prognostic factors
Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong
National Healthcare Group Eye Institute, Singapore
* The authors have no financial or proprietary interest in the subject of this topic

2. OBJECTIVE & METHODS Objective: To review the:
Epidemiology
Natural history
Prognostic factors
of myopic choroidal neovascularisation (CNV), a potentially blinding condition.
Methods:
Systematic PubMed search was performed to review English- language publications on myopic CNV

3. RESULTS High myopia was the aetiological factor in 62% of cases
One study of 354 eyes with myopic CNV demonstrated that 96% of choroidal neovascular membranes remained stable or regressed with scarring.
However, the visual prognosis of untreated myopic CNV is poor, with final visual acuities (VA) of 20/100 or less in several studies.

4. RESULTS Review of 100 untreated eyes After 5 years
100% of lesions involved the foveal center
Mean visual acuity of 20/160.
Visual acuity significantly lower than similar group treated with laser photocoagulation
10-year follow-up of 27 Asian eyes
VA dropped to 20/200 or worse
After 5 years: 88.9%
After 10 years: 96.3%
Prognostic factors for visual outcome of myopic CNV
Age at onset of CNV
Location and size of CNV
Initial best-corrected visual acuity.

5. RESULTS

6. CONCLUSION
Pathologic myopia is the cause of CNV in a large proportion of patients
Younger than 50 years of age
Long-term visual prognosis of untreated CNV is poor
Visual acuities of 20/100 or less
After 5 to 10 years in a large proportion of patients