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Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than.

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Presentation on theme: "Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than."— Presentation transcript:

1 Concentration of vascular endothelial growth factor released by cultured human luteinized granulosa cells is higher in women with polycystic ovaries than in women with normal ovaries  Rina Agrawal, M.D., Ph.D., Howard Jacobs, F.R.C.O.G.F.R.C.P., Nadia Payne, M.S.C., Gerard Conway, F.R.C.P.  Fertility and Sterility  Volume 78, Issue 6, Pages (December 2002) DOI: /S (02)

2 FIGURE 1 Time and dose–response curve for vascular endothelial growth factor (VEGF) concentrations 1, 2, 4, 6, 9, and 12 days after culture with hormone concentrations of 0.1 IU (squares), 0.5 IU (diamonds), 1.0 IU (circles), and 5.0 IU (triangles) of hCG. Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility  , DOI: ( /S (02) )

3 FIGURE 2 Release of vascular endothelial growth factor (VEGF) by granulosa lutein cells obtained from women with polycystic ovaries or the polycystic ovary syndrome (shaded bars) and women with normal ovaries (black bars). Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility  , DOI: ( /S (02) )

4 FIGURE 3 Release of vascular endothelial growth factor (VEGF) by granulosa lutein cells obtained from women with polycystic ovaries (n = 10) who developed the ovarian hyperstimulation syndrome (n = 4) (shaded bars) and those who did not develop the ovarian hyperstimulation syndrome (n=6) (black bars) after 4 days of incubation with hCG and hCG plus insulin at a concentration of 1.0 IU. Agrawal. VEGF released by human granulosa lutein cells. Fertil Steril 2002. Fertility and Sterility  , DOI: ( /S (02) )


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