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Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells  Sun Ying, MD, PhD,

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Presentation on theme: "Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells  Sun Ying, MD, PhD,"— Presentation transcript:

1 Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells  Sun Ying, MD, PhD, Qiu Meng, MD, Glenis Scadding, MD, Abhi Parikh, MS, Chris J. Corrigan, MD, PhD, Tak H. Lee, MD, DSc  Journal of Allergy and Clinical Immunology  Volume 117, Issue 2, Pages (February 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Typical patterns of immunoreactivity for EP1 (A, B), EP2 (C, D), EP3 (E, F) and EP4 (G, H) receptors in nasal mucosal sections from a normal control (A, C, E, G, respectively) and a patient with aspirin-sensitive polypoid rhinosinusitis (B, D, F, and H, respectively). Using the avidin-biotin complex method, positive cells are stained brown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Percentages of tubulin-β+ epithelial cells, Muc-5AC+ goblet cells, and CD90+ fibroblasts expressing immunoreactivity for EP1, EP2, EP3, and EP4 receptors in nasal mucosal sections from aspirin-sensitive (n = 12) and nonaspirin-sensitive polypoid rhinosinusitis (n = 10) and normal controls (n = 9). Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Percentages of inflammatory leukocytes (CD68+ macrophages, elastase+ neutrophils, tryptase+ mast cells, MBP+ eosinophils, and CD3+ T cells) expressing immunoreactivity for EP1 (top left), EP2 (top right), EP3 (bottom left), and EP4 (bottom right) in patients with aspirin-sensitive (□, n = 12), and nonaspirin-sensitive polypoid rhinosinusitis (▪, n = 10). Mann-Whitney U test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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