1. Blood Tfr cells are indicators of ongoing humoral activity.
Blood Tfr cells are indicators of ongoing humoral activity. (A) Frequency of total Treg cells, Tfr cells, and CXCR5− Treg cells in peripheral blood of SS patients and age-matched HDs (n = 25; unpaired Student’s t test with Welch’s correction for variance). Representative plots (left) and pooled data (right) are shown. (B) Blood Tfr/Tfh ratio in SS patients and HDs (n = 25; unpaired Student’s t test with Welch’s correction for variance). (C) Blood Tfr/Tfh ratio in SS patients with and without serum autoantibodies (AAb) (anti-SSA/Ro52, anti-SSB/Ro60, and anti-SSB/La) (n = 25; unpaired Student’s t test). (D) Variation of blood Tfr/Tfh ratio according to C-reactive protein (CRP). Analysis by linear regression was used. (E) Variation of blood Tfr/Tfh ratio according to disease severity score (ESSDAI). Analysis by linear regression was used. Bars represent SEM (A and C) or minimum and maximum values (in box and whisker graphs) (C).
Valter R. Fonseca et al. Sci. Immunol. 2017;2:eaan1487
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