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Overview of the actions of SGLT2, including the role of SGLT2 in glucose reabsorption in the proximal tubule (A) and sites of action at which SGLT2 inhibitors alter glycemia (B). Overview of the actions of SGLT2, including the role of SGLT2 in glucose reabsorption in the proximal tubule (A) and sites of action at which SGLT2 inhibitors alter glycemia (B). Figure A is reprinted with permission from Macmillan Publishers Ltd.: Nature Reviews Drug Discovery (ref. 67), copyright Figure B is adapted from ref. 68. Richard E. Pratley, and Eugenio Cersosimo Clin Diabetes 2017;35: ©2017 by American Diabetes Association
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