1. Tracking Stem Cell Implants in Cartilage Defects of Minipigs by Using Ferumoxytol-enhanced MRI.
At week 2 after implantation into cartilage defects, matrix-associated stem cell implants (MASIs) labeled with ferumoxytol showed higher T2 relaxation times at MRI (indicating a loss of iron signal) when they were apoptotic versus when they were viable (27 msec ± 5 vs 21 msec ± 5; P = .001).
Standard MRI showed incomplete cartilage repair of apoptotic MASIs only after 24 weeks.
Ferumoxytol labeled and unlabeled matrix associated stem cell implants (MASI) in a Göttingen minipig
Theruvath AJ et al.Published Online: May 7, 2019