1. Disease Activity at 52 Weeks (ITT population)
ACR50
ACR70
Low disease activity
DAS28 remission (<2.6)
TCZ 4 mg/kg
29%
16%
45%
30%
TCZ 8 mg/kg
36%
20%
64%
47%
Placebo
10% 4%
19% 8%

2. Total Sharp-Genant score Joint space narrowing score
Radiographic Progression at 52 Weeks (ITT population)
Total Sharp-Genant score
Erosion score
Joint space narrowing score
TCZ 4 mg/kg
0.34
0.21
0.13
TCZ 8 mg/kg
0.29
0.17
0.12
Placebo
1.13
0.71
0.42

3. Week 24: Overall ITT Population
ACR20
ACR50
ACR70
EULAR response
(Good/moderate)
DAS28 remission
TCZ
69.9%
44.1%
28%
40.2%/42%
33.6%
MTX
52.5%
33.5%
15.1%
16.9%/47.9%
12.1%