1. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
Chapter 83
Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis

2. Aminoglycosides: Bactericidal Inhibitors of Protein Synthesis
Can cause serious injury to inner ear and kidney
Narrow spectrum antibiotic
Microbial resistance
Use: aerobic gram-negative bacilli
Adverse effects
Nephrotoxicity
Ototoxicity
Hypersensitivity reactions
– Neuromuscular blockade
Drug interactions

3. Gentamicin (Garamycin)
Serious infections caused by aerobic gram-negative bacilli
Uses
Pseudomonas aeruginosa
Escherichia coli
Klebsiella
Serratia
– Proteus mirabilis
Adverse effects
Nephrotoxicity
Ototoxicity

4. Other Aminoglycosides
Tobramycin (Nebcin)
Amikacin (Amikin)
Netilmicin (Netromycin)
Neomycin
Kanamycin (Kantrex)
Streptomycin
Paromomycin (Humatin)